<Suppliers Price>

NFPS

Names

[ CAS No. ]:
405225-21-0

[ Name ]:
NFPS

[Synonym ]:
alx5407
nfps

Biological Activity

[Description]:

NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively[1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GlyT

[Target]

hGlyT1:2.8 nM (IC50)

rGlyT1:9.8 nM (IC50)


[References]

[1]. Mallorga PJ, et al. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology. 2003 Oct;45(5):585-93.

[2]. Huang B, et al. GlyT1 Inhibitor NFPS Exerts Neuroprotection via GlyR Alpha1 Subunit in the Rat Model of Transient Focal Cerebral Ischaemia and Reperfusion. Cell Physiol Biochem. 2016;38(5):1952-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24FNO3

[ Molecular Weight ]:
393.45100

[ Exact Mass ]:
393.17400

[ PSA ]:
49.77000

[ LogP ]:
5.01930

Related Compounds