405225-21-0

405225-21-0 structure

Name: NFPS
Chemical Name: 2-[[3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid
CAS Number: 405225-21-0
Molecular Formula: C₂₄H₂₄FNO₃
Molecular Weight: 393.45100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GlyT
Create Date: 2017-05-03 02:13:29
Modify Date: 2025-08-25 07:59:32
NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively[1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion[2].

Name	2-[[3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid
Synonyms	alx5407 nfps

Description	NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively[1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GlyT
Target	hGlyT1:2.8 nM (IC50) rGlyT1:9.8 nM (IC50)
References	[1]. Mallorga PJ, et al. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology. 2003 Oct;45(5):585-93. [2]. Huang B, et al. GlyT1 Inhibitor NFPS Exerts Neuroprotection via GlyR Alpha1 Subunit in the Rat Model of Transient Focal Cerebral Ischaemia and Reperfusion. Cell Physiol Biochem. 2016;38(5):1952-62.