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SDZ 21009

Names

[ CAS No. ]:
39731-05-0

[ Name ]:
SDZ 21009

Biological Activity

[Description]:

Carpindolol (SDZ21009) is a 5-HT1B receptor antagonist (pKd of 8.53 and pKB of 8.0) and a 5-HT1D receptor agonist (pEC50 of 5.91 and pKd of 6.37)[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1B Receptor:8.53 (pKd)

5-HT1D Receptor:5.91 (pEC50)

5-HT1D Receptor:6.37 (pKd)


[References]

[1]. P Schoeffter, et al. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1989 Sep;340(3):285-92.  

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
529.8ºC at 760mmHg

[ Molecular Formula ]:
C19H28N2O4

[ Molecular Weight ]:
348.44

[ Flash Point ]:
274.2ºC

[ Exact Mass ]:
348.20500

[ PSA ]:
83.58000

[ LogP ]:
3.25180

[ Index of Refraction ]:
1.567

Related Compounds