39731-05-0

39731-05-0 structure

Name: SDZ 21009
Chemical Name: propan-2-yl 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carboxylate
CAS Number: 39731-05-0
Molecular Formula: C₁₉H₂₈N₂O₄
Molecular Weight: 348.44
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-03-21 08:00:00
Modify Date: 2025-08-26 20:52:15
Carpindolol (SDZ21009) is a 5-HT1B receptor antagonist (pKd of 8.53 and pKB of 8.0) and a 5-HT1D receptor agonist (pEC50 of 5.91 and pKd of 6.37)[1].

Name	propan-2-yl 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carboxylate

Description	Carpindolol (SDZ21009) is a 5-HT1B receptor antagonist (pKd of 8.53 and pKB of 8.0) and a 5-HT1D receptor agonist (pEC50 of 5.91 and pKd of 6.37)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1B Receptor:8.53 (pKd) 5-HT1D Receptor:5.91 (pEC50) 5-HT1D Receptor:6.37 (pKd)
References	[1]. P Schoeffter, et al. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1989 Sep;340(3):285-92.