(±)-Befunolol
Names
Biological Activity
[Description]:
(±)-Befunolol is a β-adrenoceptor blocking agent.
[Related Catalog]:
[Target]
Adrenoreceptor[1]
[In Vitro]
A β-adrenoceptor blocking agent, Befunolol, is found to has intrinsic sympathomimetic activities in isolated right atria, trachea and taenia caecum of guinea pig (intrinsic activities are 0.22-0.28). The pD2-values of Befunolol estimated in the isolated organs are significantly different from its pA2-values against isoprenaline. Befunolol interacts with the beta-adrenoceptor where there may be two different sites: one site for agonistic action and the other for competitive antagonistic action. The intrinsic activity of Befunolol may be equal to its selectivity for both the sites[1].
[References]
[Related Small Molecules]
Isoprenaline hydrochloride
|
ICI 118,551 (hydrochloride)
|
Phenylephrine hydrochloride
|
Yohimbine hydrochloride
|
Adrenaline
|
Ivabradine hydrochloride
|
Prazosin hydrochloride
|
Clenbuterol hydrochloride
|
Phentolamine mesilate
|
guanfacine hydrochloride
|
pimozide
|
Sotalol hydrochloride
|
Carvedilol
|
Atenolol
|
Metroprolol succinate
Chemical & Physical Properties
[ Density]:
1.1049 (rough estimate)
[ Boiling Point ]:
433.35°C (rough estimate)
[ Melting Point ]:
115°
[ Molecular Formula ]:
C16H21NO4
[ Molecular Weight ]:
291.34200
[ Exact Mass ]:
291.14700
[ PSA ]:
71.70000
[ LogP ]:
2.76400
[ Index of Refraction ]:
1.5500 (estimate)
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OB4310000
- CHEMICAL NAME :
- Ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofurany l methyl
- CAS REGISTRY NUMBER :
- 39552-01-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C16-H21-N-O4
- MOLECULAR WEIGHT :
- 291.38
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2223184
Safety Information
[ HS Code ]:
2932999099
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932999099
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%