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39552-01-7

39552-01-7 structure
39552-01-7 structure
  • Name: (±)-Befunolol
  • Chemical Name: 1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone
  • CAS Number: 39552-01-7
  • Molecular Formula: C16H21NO4
  • Molecular Weight: 291.34200
  • Catalog: API Circulatory system medication Antiarrhythmic drug
  • Create Date: 2018-06-17 16:22:38
  • Modify Date: 2024-01-03 03:20:12
  • (±)-Befunolol is a β-adrenoceptor blocking agent.
Name 1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone
Synonyms Befunolol HCl
(±)-Befunolol
Description (±)-Befunolol is a β-adrenoceptor blocking agent.
Related Catalog
Target

Adrenoreceptor[1]
In Vitro A β-adrenoceptor blocking agent, Befunolol, is found to has intrinsic sympathomimetic activities in isolated right atria, trachea and taenia caecum of guinea pig (intrinsic activities are 0.22-0.28). The pD2-values of Befunolol estimated in the isolated organs are significantly different from its pA2-values against isoprenaline. Befunolol interacts with the beta-adrenoceptor where there may be two different sites: one site for agonistic action and the other for competitive antagonistic action. The intrinsic activity of Befunolol may be equal to its selectivity for both the sites[1].
References

[1]. Takayanagi I, et al. A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs. Gen Pharmacol. 1985;16(3):265-7.
Density 1.1049 (rough estimate)
Boiling Point 433.35°C (rough estimate)
Melting Point 115°
Molecular Formula C16H21NO4
Molecular Weight 291.34200
Exact Mass 291.14700
PSA 71.70000
LogP 2.76400
Index of Refraction 1.5500 (estimate)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OB4310000
CHEMICAL NAME :
Ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofurany l methyl
CAS REGISTRY NUMBER :
39552-01-7
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H21-N-O4
MOLECULAR WEIGHT :
291.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2223184
HS Code 2932999099
53943-39-8 structure

53943-39-8

~%

39552-01-7 structure

39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
39552-12-0 structure

39552-12-0
75-26-3 structure

75-26-3

~%

39552-01-7 structure

39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
39552-17-5 structure

39552-17-5

~%

39552-01-7 structure

39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
39552-18-6 structure

39552-18-6

~%

39552-01-7 structure

39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
39552-00-6 structure

39552-00-6
75-31-0 structure

75-31-0
106-89-8 structure

106-89-8

~%

39552-01-7 structure

39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
55636-92-5 structure

55636-92-5

~%

39552-01-7 structure

39552-01-7
Literature: Ohara, Hirotami; Miyabe, Yoshiyuki; Deyashiki, Yoshihiro; Matsuura, Kazuya; Hara, Akira Biochemical Pharmacology, 1995 , vol. 50, # 2 p. 221 - 227
39543-77-6 structure

39543-77-6
75-31-0 structure

75-31-0

~%

39552-01-7 structure

39552-01-7
Literature: Ohishi, Yoshitaka; Nakanishi, Teruo Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 10 p. 3418 - 3423
HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 39552-01-7 | Chemsrc address: https://www.chemsrc.com/en/baike/82217.html

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