(±)-Befunolol

Modify Date: 2024-01-03 03:20:12

(±)-Befunolol Structure
(±)-Befunolol structure
 Common Name (±)-Befunolol
CAS Number 39552-01-7 Molecular Weight 291.34200
Density 1.1049 (rough estimate) Boiling Point 433.35°C (rough estimate)
Molecular Formula C16H21NO4 Melting Point 115°
MSDS N/A Flash Point N/A

 Use of (±)-Befunolol


(±)-Befunolol is a β-adrenoceptor blocking agent.

 Names

Name 1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone
Synonym More Synonyms

 (±)-Befunolol Biological Activity

Description (±)-Befunolol is a β-adrenoceptor blocking agent.
Related Catalog
Target

Adrenoreceptor[1]
In Vitro A β-adrenoceptor blocking agent, Befunolol, is found to has intrinsic sympathomimetic activities in isolated right atria, trachea and taenia caecum of guinea pig (intrinsic activities are 0.22-0.28). The pD2-values of Befunolol estimated in the isolated organs are significantly different from its pA2-values against isoprenaline. Befunolol interacts with the beta-adrenoceptor where there may be two different sites: one site for agonistic action and the other for competitive antagonistic action. The intrinsic activity of Befunolol may be equal to its selectivity for both the sites[1].
References

[1]. Takayanagi I, et al. A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs. Gen Pharmacol. 1985;16(3):265-7.

 Chemical & Physical Properties

Density 1.1049 (rough estimate)
Boiling Point 433.35°C (rough estimate)
Melting Point 115°
Molecular Formula C16H21NO4
Molecular Weight 291.34200
Exact Mass 291.14700
PSA 71.70000
LogP 2.76400
Index of Refraction 1.5500 (estimate)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OB4310000
CHEMICAL NAME :
Ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofurany l methyl
CAS REGISTRY NUMBER :
39552-01-7
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H21-N-O4
MOLECULAR WEIGHT :
291.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2223184

 Safety Information

HS Code 2932999099

 Synthetic Route

3-isopropyl-5-(2-acetyl-7-benzofuranoxymethyl)oxazolidone structure

3-isopropyl-5-(...

CAS#:53943-39-8

~%

(±)-Befunolol Structure

(±)-Befunolol

CAS#:39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
2-acetyl-7-(2-hydroxy-3-aminopropoxy)benzofuran structure

2-acetyl-7-(2-h...

CAS#:39552-12-0
2-Bromopropane structure

2-Bromopropane

CAS#:75-26-3

~%

(±)-Befunolol Structure

(±)-Befunolol

CAS#:39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
2-phenyl-3-isopropyl-5-(2-acetyl-7-benzofuranoxymethyl)oxazolidine structure

2-phenyl-3-isop...

CAS#:39552-17-5

~%

(±)-Befunolol Structure

(±)-Befunolol

CAS#:39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
2-acetyl-7-[2-hydroxy-3-(N-acetyl-N-isopropyl)aminopropoxy]benzofuran structure

2-acetyl-7-[2-h...

CAS#:39552-18-6

~%

(±)-Befunolol Structure

(±)-Befunolol

CAS#:39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
2-acetyl-7-hydroxybenzo[b]furan potassium salt structure

2-acetyl-7-hydr...

CAS#:39552-00-6
isopropylamine structure

isopropylamine

CAS#:75-31-0
Epichlorohydrin structure

Epichlorohydrin

CAS#:106-89-8

~%

(±)-Befunolol Structure

(±)-Befunolol

CAS#:39552-01-7
Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A
2-(hydroxyethyl)-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran structure

2-(hydroxyethyl...

CAS#:55636-92-5

~%

(±)-Befunolol Structure

(±)-Befunolol

CAS#:39552-01-7
Literature: Ohara, Hirotami; Miyabe, Yoshiyuki; Deyashiki, Yoshihiro; Matsuura, Kazuya; Hara, Akira Biochemical Pharmacology, 1995 , vol. 50, # 2 p. 221 - 227
2-acetyl-7-glycidyloxybenzo[b]furan structure

2-acetyl-7-glyc...

CAS#:39543-77-6
isopropylamine structure

isopropylamine

CAS#:75-31-0

~%

(±)-Befunolol Structure

(±)-Befunolol

CAS#:39552-01-7
Literature: Ohishi, Yoshitaka; Nakanishi, Teruo Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 10 p. 3418 - 3423

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Befunolol HCl
(±)-Befunolol
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