(±)-Befunolol
(±)-Befunolol structure
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Common Name | (±)-Befunolol | ||
|---|---|---|---|---|
| CAS Number | 39552-01-7 | Molecular Weight | 291.34200 | |
| Density | 1.1049 (rough estimate) | Boiling Point | 433.35°C (rough estimate) | |
| Molecular Formula | C16H21NO4 | Melting Point | 115° | |
| MSDS | N/A | Flash Point | N/A | |
Use of (±)-Befunolol(±)-Befunolol is a β-adrenoceptor blocking agent. |
| Name | 1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone |
|---|---|
| Synonym | More Synonyms |
| Description | (±)-Befunolol is a β-adrenoceptor blocking agent. |
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| Related Catalog | |
| Target |
Adrenoreceptor[1] |
| In Vitro | A β-adrenoceptor blocking agent, Befunolol, is found to has intrinsic sympathomimetic activities in isolated right atria, trachea and taenia caecum of guinea pig (intrinsic activities are 0.22-0.28). The pD2-values of Befunolol estimated in the isolated organs are significantly different from its pA2-values against isoprenaline. Befunolol interacts with the beta-adrenoceptor where there may be two different sites: one site for agonistic action and the other for competitive antagonistic action. The intrinsic activity of Befunolol may be equal to its selectivity for both the sites[1]. |
| References |
| Density | 1.1049 (rough estimate) |
|---|---|
| Boiling Point | 433.35°C (rough estimate) |
| Melting Point | 115° |
| Molecular Formula | C16H21NO4 |
| Molecular Weight | 291.34200 |
| Exact Mass | 291.14700 |
| PSA | 71.70000 |
| LogP | 2.76400 |
| Index of Refraction | 1.5500 (estimate) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2932999099 |
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(±)-Befunolol CAS#:39552-01-7 |
| Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A |
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(±)-Befunolol CAS#:39552-01-7 |
| Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A |
|
~%
(±)-Befunolol CAS#:39552-01-7 |
| Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A |
|
~%
(±)-Befunolol CAS#:39552-01-7 |
| Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A |
|
~%
(±)-Befunolol CAS#:39552-01-7 |
| Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A |
|
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(±)-Befunolol CAS#:39552-01-7 |
| Literature: Ohara, Hirotami; Miyabe, Yoshiyuki; Deyashiki, Yoshihiro; Matsuura, Kazuya; Hara, Akira Biochemical Pharmacology, 1995 , vol. 50, # 2 p. 221 - 227 |
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(±)-Befunolol CAS#:39552-01-7 |
| Literature: Ohishi, Yoshitaka; Nakanishi, Teruo Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 10 p. 3418 - 3423 |
![2-acetyl-7-[2-hydroxy-3-(N-acetyl-N-isopropyl)aminopropoxy]benzofuran structure](https://image.chemsrc.com/caspic/445/39552-18-6.png)
![2-acetyl-7-hydroxybenzo[b]furan potassium salt structure](https://image.chemsrc.com/caspic/466/39552-00-6.png)
![2-acetyl-7-glycidyloxybenzo[b]furan structure](https://image.chemsrc.com/caspic/200/39543-77-6.png)
| Precursor 10 | |
|---|---|
| DownStream 1 | |
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Befunolol HCl |
| (±)-Befunolol |