GS 39783

Names

[ Name ]:
GS 39783

[Synonym ]:
Tocris-2001
N,N'-dicyclopentyl-2-methylsulfanyl-5-nitropyrimidine-4,6-diamine
N4,N6-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine

Biological Activity

[Description]:

GS39783 is a positive allosteric modulator (PAM) of GABABR. Positive modulation of the GABABR can be used for the research of Nicotine addiction[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Emmanuel Sturchler, et al. GABA B receptor allosteric modulators exhibit pathway-dependent and species-selective activity. Pharmacol Res Perspect. 2017 Mar 24;5(2):e00288.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
561.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₃N₅O₂S

[ Molecular Weight ]:
337.44000

[ Flash Point ]:
293.7ºC

[ Exact Mass ]:
337.15700

[ PSA ]:
120.96000

[ LogP ]:
4.48490

[ Index of Refraction ]:
1.614

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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