GW297361

Names

[ Name ]:
GW297361

Biological Activity

[Description]:

GW297361 is an oxindole CDK inhibitor that elicits a Pho85-selective response in cells. GW297361 inhibits yeast Cdk1 and Pho85 with IC50s of 20 nM and 400 nM in vitro, respectively[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

yeast Cdk1:20 nM (IC50)

yeast Pho85:400 nM (IC50)

human CDK2:1.9 nM (IC50)

human CDK9:10 nM (IC50)

human CDK1:30 nM (IC50)

human CDK4:300 nM (IC50)

VEGFR2:120 nM (IC50)

SRC:930 nM (IC50)

[In Vitro]

GW297361 (20 μM; 15 min) 部分抑制细胞内的 Cdk1[1]。 Western Blot Analysis[1] Cell Line: YRP1 cells Concentration: 20 μM Incubation Time: 20 μM Result: An intermediate level of the Orc6 was converted to the faster-migrating isoform (lower:upper = 2:1).

[References]

[1]. Kung C, et al. Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. 2006 Apr;13(4):399-407.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂N₄O₃S₂

[ Molecular Weight ]:
372.42

GW297361

Names

Biological Activity

Chemical & Physical Properties

Related Compounds