2'-(o-methyl)-inosine

Names

[ Name ]:
2'-(o-methyl)-inosine

[Synonym ]:
2'-O-methylinosine
O2'-methyl-inosine

Biological Activity

[Description]:

9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-ol (2'-O-methylinosine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.844g/cm3

[ Boiling Point ]:
669.568ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₄N₄O₅

[ Molecular Weight ]:
282.25

[ Flash Point ]:
358.742ºC

[ Exact Mass ]:
282.09600

[ PSA ]:
122.49000

[ Appearance of Characters ]:
Powder | White to Off-white

[ Index of Refraction ]:
1.774

[ Water Solubility ]:
Slightly soluble in water.

Precursor & DownStream

Precursor

DownStream

Related Compounds

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