Fuberidazole
Names
[ CAS No. ]:
3878-19-1
[ Name ]:
Fuberidazole
[Synonym ]:
Fubridazole
EINECS 223-404-0
2-(2-Furanyl)-1H-benzimidazole
2-(furan-2-yl)-benzimidazole
2-(furan-2-yl)-1H-benzo[d]imidazole
Benzimidazole,2-(2-furyl)
2-(furan-2-yl)-1H-benzimidazole
Fuberidatol
2-(2'-furyl)-benzimidazole
Voronite
Fuberidazol
Furidazole
Furidazol
MFCD00055496
2-(2-furyl)benzimidazole
Fuberisazol
2-(furan-2-yl)-1H-1,3-benzimidazole
2-(2'-furyl)-1H-benzimidazole
Voronit
Biological Activity
[Description]:
[Related Catalog]:
[Target]
B. cinerea[1]
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.286g/cm3
[ Boiling Point ]:
380.6ºC at 760 mmHg
[ Melting Point ]:
310-312℃
[ Molecular Formula ]:
C11H8N2O
[ Molecular Weight ]:
184.19
[ Flash Point ]:
194.7ºC
[ Exact Mass ]:
184.06400
[ PSA ]:
41.82000
[ LogP ]:
2.82290
[ Index of Refraction ]:
1.67
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DD9010000
- CHEMICAL NAME :
- Benzimidazole, 2-(2-furyl)-
- CAS REGISTRY NUMBER :
- 3878-19-1
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C11-H8-N2-O
- MOLECULAR WEIGHT :
- 184.21
- WISWESSER LINE NOTATION :
- T56 BM DNJ C- BT5OJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 330 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 825 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 15,273,1972 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,151,1975
Safety Information
[ Symbol ]:
GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H311-H317-H330-H351-H373-H410
[ Precautionary Statements ]:
P260-P273-P280-P284-P304 + P340 + P310-P403 + P233
[ Target Organs ]:
Heart
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn,N
[ Risk Phrases ]:
R22:Harmful if swallowed. R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
[ Safety Phrases ]:
S22-S60-S61
[ RIDADR ]:
2588
[ WGK Germany ]:
3.0
[ RTECS ]:
DD9010000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2934999090
Synthetic Route
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Bioorg. Med. Chem. Lett. 20 , 4038-44, (2010)
Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype ...
Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions.J. Med. Chem. 49 , 511-22, (2006)
We report the discovery of thiabendazole as a potent inhibitor (K(i) = 0.4 microM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabenda...
Quantitative Fusarium spp. and Microdochium spp. PCR assays to evaluate seed treatments for the control of Fusarium seedling blight of wheat.J. Appl. Microbiol. 102(6) , 1645-53, (2007)
To develop sensitive quantitative PCR assays for the two groups of pathogens responsible for Fusarium seedling blight in wheat: Fusarium group (Fusarium culmorum and Fusarium graminearum) and Microdoc...