Rubrofusarin

Names

[ Name ]:
Rubrofusarin

[Synonym ]:
rubrofusarin B
5,6-Dihydroxy-8-methoxy-2-methyl-4H-naphtho<2,3-b>pyran-4-on
Rubrofusarin
RUBRAFUSARIN
Rubofusarin
5,6-dihydroxy-8-methoxy-2-methylbenzo[g]chromen-4-one

Biological Activity

[Description]:

Rubrofusarin is an orange polyketide pigment from Fusarium graminearum[1]. Rubrofusarin is also an active ingredient of the Cassia species and ameliorates chronic restraint stress (CRS) -induced depressive symptoms through PI3K/Akt signaling. Rubrofusarin has anticancer, antibacterial, and antioxidant effects[2][3].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Hiroshi Tanaka, et al. The Chemical Constitution of Rubrofusarin, a Pigment from Fusarium graminearum. Agricultural and Biological Chemistry, 26:11, 767-770.

[2]. Peter Rugbjerg, et al. Reconstruction of the biosynthetic pathway for the core fungal polyketide scaffold rubrofusarin in Saccharomyces cerevisiae. Microb Cell Fact. 2013 Apr 4;12:31.

[3]. Jee Hyun Yi , et al. Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms. Int J Mol Sci. 2020 May 13;21(10):3454.

Chemical & Physical Properties

[ Density]:
1.432g/cm3

[ Boiling Point ]:
438.7ºC at 760mmHg

[ Melting Point ]:
210 - 211 °C

[ Molecular Formula ]:
C₁₅H₁₂O₅

[ Molecular Weight ]:
272.25300

[ Flash Point ]:
167ºC

[ Exact Mass ]:
272.06800

[ PSA ]:
79.90000

[ LogP ]:
2.67440

[ Index of Refraction ]:
1.691

[ Storage condition ]:
20°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%