Fmoc-Gly-Gly-OH

Names

[ Name ]:
Fmoc-Gly-Gly-OH

[Synonym ]:
N-9-fluorenylmethoxycarbonyl-glycyl-glycine
Fmoc-Gly-Gly
2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)acetamido)acetic acid
Fmoc-Gly-Gly-OH
Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine
FMOC-GLYCYL-GLYCINE

Biological Activity

[Description]:

Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
684.1±45.0 °C at 760 mmHg

[ Melting Point ]:
182 °C

[ Molecular Formula ]:
C₁₉H₁₈N₂O₅

[ Molecular Weight ]:
354.357

[ Flash Point ]:
367.5±28.7 °C

[ Exact Mass ]:
354.121582

[ PSA ]:
104.73000

[ LogP ]:
2.37

[ Appearance of Characters ]:
Powder | White

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.613

[ Storage condition ]:
-15°C

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%