Fmoc-Gly-Gly-OH

Modify Date: 2024-01-08 22:19:37

Fmoc-Gly-Gly-OH Structure
Fmoc-Gly-Gly-OH structure
Common Name Fmoc-Gly-Gly-OH
CAS Number 35665-38-4 Molecular Weight 354.357
Density 1.3±0.1 g/cm3 Boiling Point 684.1±45.0 °C at 760 mmHg
Molecular Formula C19H18N2O5 Melting Point 182 °C
MSDS N/A Flash Point 367.5±28.7 °C

 Use of Fmoc-Gly-Gly-OH


Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name 2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetic acid
Synonym More Synonyms

 Fmoc-Gly-Gly-OH Biological Activity

Description Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 684.1±45.0 °C at 760 mmHg
Melting Point 182 °C
Molecular Formula C19H18N2O5
Molecular Weight 354.357
Flash Point 367.5±28.7 °C
Exact Mass 354.121582
PSA 104.73000
LogP 2.37
Appearance of Characters Powder | White
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.613
Storage condition -15°C

 Safety Information

HS Code 2924299090

 Synthetic Route

~77%

Fmoc-Gly-Gly-OH Structure

Fmoc-Gly-Gly-OH

CAS#:35665-38-4

Literature: Kupihar, Zoltan; Schmel, Zoltan; Kele, Zoltan; Penke, Botond; Kovacs, Lajos Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1241 - 1247

~90%

Fmoc-Gly-Gly-OH Structure

Fmoc-Gly-Gly-OH

CAS#:35665-38-4

Literature: Ibrahim, Tarek S.; Tala, Srinivasa R.; El-Feky, Said A.; Abdel-Samii, Zakaria K.; Katritzky, Alan R. Synlett, 2011 , # 14 art. no. S03511ST, p. 2013 - 2016

~%

Fmoc-Gly-Gly-OH Structure

Fmoc-Gly-Gly-OH

CAS#:35665-38-4

Literature: Journal of the American Chemical Society, , vol. 125, # 45 p. 13680 - 13681

~%

Fmoc-Gly-Gly-OH Structure

Fmoc-Gly-Gly-OH

CAS#:35665-38-4

Literature: Journal of the American Chemical Society, , vol. 125, # 45 p. 13680 - 13681

~%

Fmoc-Gly-Gly-OH Structure

Fmoc-Gly-Gly-OH

CAS#:35665-38-4

Literature: Journal of Organic Chemistry, , vol. 37, # 22 p. 3404 - 3409

~%

Fmoc-Gly-Gly-OH Structure

Fmoc-Gly-Gly-OH

CAS#:35665-38-4

Literature: Synlett, , # 14 art. no. S03511ST, p. 2013 - 2016

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

N-9-fluorenylmethoxycarbonyl-glycyl-glycine
Fmoc-Gly-Gly
2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)acetamido)acetic acid
Fmoc-Gly-Gly-OH
Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine
FMOC-GLYCYL-GLYCINE
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