| Name | 2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetic acid |
|---|---|
| Synonyms |
N-9-fluorenylmethoxycarbonyl-glycyl-glycine
Fmoc-Gly-Gly 2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)acetamido)acetic acid Fmoc-Gly-Gly-OH Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine FMOC-GLYCYL-GLYCINE |
| Description | Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 684.1±45.0 °C at 760 mmHg |
| Melting Point | 182 °C |
| Molecular Formula | C19H18N2O5 |
| Molecular Weight | 354.357 |
| Flash Point | 367.5±28.7 °C |
| Exact Mass | 354.121582 |
| PSA | 104.73000 |
| LogP | 2.37 |
| Appearance | Powder | White |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.613 |
| Storage condition | -15°C |
| HS Code | 2924299090 |
|---|
|
~77%
35665-38-4 |
| Literature: Kupihar, Zoltan; Schmel, Zoltan; Kele, Zoltan; Penke, Botond; Kovacs, Lajos Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1241 - 1247 |
|
~90%
35665-38-4 |
| Literature: Ibrahim, Tarek S.; Tala, Srinivasa R.; El-Feky, Said A.; Abdel-Samii, Zakaria K.; Katritzky, Alan R. Synlett, 2011 , # 14 art. no. S03511ST, p. 2013 - 2016 |
|
~%
35665-38-4 |
| Literature: Journal of the American Chemical Society, , vol. 125, # 45 p. 13680 - 13681 |
|
~%
35665-38-4 |
| Literature: Journal of the American Chemical Society, , vol. 125, # 45 p. 13680 - 13681 |
|
~%
35665-38-4 |
| Literature: Journal of Organic Chemistry, , vol. 37, # 22 p. 3404 - 3409 |
|
~%
35665-38-4 |
| Literature: Synlett, , # 14 art. no. S03511ST, p. 2013 - 2016 |
| Precursor 7 | |
|---|---|
| DownStream 0 | |
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |