9-Fluorenylmethyl chloroformate

Names

[ Name ]:
9-Fluorenylmethyl chloroformate

[Synonym ]:
9-Fluorenylmethoxycarbonyl chloride
9-Fluorenylmethyl Chloroformate [N-Protecting Agent
9-fluorenylmethyl chlorocarbonate
9-Fluorenylmethyl Chloroformate Fmoc chloride
(9H-Fluoren-9-yl)methyl chloroformate
Fmoc-Cl
9H-fluoren-9-ylmethyl chloroformate
9-Fluorenylmethyl chloroformate
Fmoc chloroformate
Fmoc chloride
Carbonochloridic acid, 9H-fluoren-9-ylmethyl ester
Chloroformic Acid 9-Fluorenylmethyl Ester
(9H-Fluoren-9-ylmethoxy)carbonyl Chloride
9H-Fluoren-9-ylmethyl carbonochloridate
9-Fluorenylmethyloxycarbonylchloride
EINECS 249-313-6
Fluorenylmethyloxycarbonyl chloride
9-Fluorenylmethoxycarbonyl chloride,9-Fluorenylmethyl chloroformate,Fmoc-Cl
1-(9-fluorenyl)methyl chloroformate
9-Fluorenylmethylchloroformate
fluoren-9-ylmethyl chloroformate
Fmoc-chloride
MFCD00001138
(9H-fluoren-9-yl)methyl carbonochloridate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
393.9±11.0 °C at 760 mmHg

[ Melting Point ]:
62-64 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₁ClO₂

[ Molecular Weight ]:
258.700

[ Flash Point ]:
143.6±11.4 °C

[ Exact Mass ]:
258.044769

[ PSA ]:
26.30000

[ LogP ]:
4.58

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.612

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
dioxane: 0.1 g/mL, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ6250000

CHEMICAL NAME :: Formic acid, chloro-, fluoren-9-ylmethyl ester

CAS REGISTRY NUMBER :: 28920-43-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H11-Cl-O2

MOLECULAR WEIGHT :: 258.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 170,23,1986

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R20/21/22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
LQ6250000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
29159020

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Effects of dietary sodium butyrate on hepatic biotransformation and pharmacokinetics of erythromycin in chickens.

J. Vet. Pharmacol. Ther. 37(4) , 406-12, (2014)

Butyrate, a commonly applied feed additive in poultry nutrition, can modify the expression of certain genes, including those encoding cytochrome P450 (CYP) enzymes. In comparative in vitro and in vivo...

Analysis of amino acids by HPLC/electrospray negative ion tandem mass spectrometry using 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) derivatization.

Amino Acids 46(12) , 2799-808, (2014)

A new method for the determination of amino acids is presented. It combines established methods for the derivatization of primary and secondary amino groups with 9-fluorenylmethoxycarbonyl chloride (F...

Development and validation of a high-performance liquid chromatography-fluorescence detection method for the accurate quantification of colistin in human plasma.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 48-54, (2015)

Recently, colistin has become one of the most important drugs for treating infections caused by multidrug-resistant Gram-negative bacteria. Therapeutic drug monitoring is recommended to ensure the saf...