9-AMINO-6-CHLORO-2-METHOXYACRIDINE

Names

[ Name ]:
9-AMINO-6-CHLORO-2-METHOXYACRIDINE

[Synonym ]:
MFCD00083236
6-chloro-2-methoxyacridin-9-amine

Biological Activity

[Description]:

9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Carqueijeiro I, et al. Analytical and Fluorimetric Methods for the Characterization of the Transmembrane Transport of Specialized Metabolites in Plants. Methods Mol Biol. 2016;1405:121-135.

Chemical & Physical Properties

[ Density]:
1.367g/cm3

[ Boiling Point ]:
475.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₁ClN₂O

[ Molecular Weight ]:
258.70300

[ Flash Point ]:
241.2ºC

[ Exact Mass ]:
258.05600

[ PSA ]:
48.14000

[ LogP ]:
4.21340

[ Index of Refraction ]:
1.734

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7330000

CHEMICAL NAME :: Acridine, 9-amino-3-chloro-7-methoxy-

CAS REGISTRY NUMBER :: 3548-09-2

BEILSTEIN REFERENCE NO. :: 0226315

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H11-Cl-N2-O

MOLECULAR WEIGHT :: 258.72

WISWESSER LINE NOTATION :: T C666 BNJ EG IZ LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year: 28,1,1947

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H351

[ Precautionary Statements ]:
P261-P281-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
AR7330000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Vma9p need not be associated with the yeast V-ATPase for fully-coupled proton pumping activity in vitro.

Biochemistry 54(3) , 853-8, (2015)

Vacuolar-type ATPases (V-ATPases) acidify numerous intracellular compartments in all eukaryotic cells and are responsible for extracellular acidification in some specialized cells. V-ATPases are large...

Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4.

Am. J. Physiol. Renal Physiol. 309 , F120-36, (2015)

We previously reported that the deletion of the pH sensor GPR4 causes a non-gap metabolic acidosis and defective net acid excretion (NAE) in the GPR4 knockout mouse (GPR4-/-) (Sun X, Yang LV, Tiegs BC...

Copper transport and compartmentation in grape cells.

Plant Cell Physiol. 53(11) , 1866-80, (2012)

Copper-based fungicides have been widely used against several grapevine (Vitis vinifera L.) diseases since the late 1800s when the Bordeaux mixture was developed, but their intensive use has raised ph...