6,9-Dichloro-2-methoxyacridine

Names

[ CAS No. ]:
86-38-4

[ Name ]:
6,9-Dichloro-2-methoxyacridine

[Synonym ]:
Halocrine
3,9-Dichloro-7-methoxyacridine
2-Methoxy-6,9-dichloroacridine
6,9-dichloro-3-methoxyacridine
BIDD:GT0206
Halocrin
6.9-dichloro-2-methoxyacridine
MFCD00005028
EINECS 201-666-7
Acridine,9-dichloro-2-methoxy

Chemical & Physical Properties

[ Density]:
1.399 g/cm3

[ Boiling Point ]:
444.3ºC at 760 mmHg

[ Melting Point ]:
163-165 °C(lit.)

[ Molecular Formula ]:
C₁₄H₉Cl₂NO

[ Molecular Weight ]:
278.13300

[ Flash Point ]:
222.5ºC

[ Exact Mass ]:
277.00600

[ PSA ]:
22.12000

[ LogP ]:
4.70340

[ Index of Refraction ]:
1.696

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H317-H319-H334-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R36/37/38;R42/43

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity.

ChemMedChem 9(2) , 305-10, (2014)

Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming increasingly resistant to most available drugs. A convenient approach to combat parasite resistance is the de...

Antimalarial acridines: Synthesis, in vitro activity againstP. falciparumand interaction with hematin

Bioorg. Med. Chem. 17(23) , 8032-9, (2009)

Synthesis of new 9-aminoacridines and evaluation of in vitro anti-malarial activity. Inhibitory effect on haem crystallization.

[Preparation and antileukemic activity of quinolizidinylalkyl-derivatives of 4-aminoquinoline and 9-aminoacridine].

Boll. Chim. Farm. 128(6) , 212-5, (1989)

By reacting three quinolizidinylalkylamines with 4,7-dichloroquinoline and 6,9-dichloro-2-methoxyacridine six derivatives of 4-aminoquinoline and 9-aminoacridine were obtained. These compounds, which ...