Anabase

Names

[ Name ]:
Anabase

[Synonym ]:
anabaseine dihydrochloride
2,3'-BIPYRIDINE,3,4,5,6-TETRAHYDRO
Anabaseine
3,4,5,6-tetrahydro-2,3'-bipyridine

Biological Activity

[Description]:

Anabaseine, an alkaloid, stimulates a wide variety of animal nicotinic acetylcholine receptors (AChRs), especially the neuromuscular receptors and α7 AChRs[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[In Vitro]

anabaseine (3.6 μmol/kg; subcutaneous injection) has a peak effect values of 50%, 85%, 62% for acetylcholine, dopamine and norepinephrine, respectively [1][2] . anabaseine act as neuromuscular agonists on the frog rectus abdominis muscle whit a EC50 of 0.25-0.74 μM[1].

[References]

[1]. [1] Kem W, et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties. Mar Drugs. 2006;4(3):255-273.

[2]. [2] Summers KL et al. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Jpn J Pharmacol. 1997 Jun;74(2):139-46.

Chemical & Physical Properties

[ Density]:
1.09g/cm3

[ Boiling Point ]:
263.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₂N₂

[ Molecular Weight ]:
160.22

[ Flash Point ]:
113.4ºC

[ Exact Mass ]:
160.10000

[ PSA ]:
25.25000

[ LogP ]:
1.49020

[ Index of Refraction ]:
1.596

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW1890000

CHEMICAL NAME :: 2,3'-Bipyridine, 3,4,5,6-tetrahydro-

CAS REGISTRY NUMBER :: 3471-05-4

BEILSTEIN REFERENCE NO. :: 0125981

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,684,1976

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%