Chromeceptin

Names

[ Name ]:
Chromeceptin

[Synonym ]:
2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene 94G6
2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile

Biological Activity

[Description]:

Chromeceptin is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the Phosphorylation levels of AKT and mTOR[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IGF-1R

[In Vitro]

Chromeceptin (94G6) (5 µM) inhibits IGF2 expression in Hep3B-derived TS cells in a time-dependent manner[1]. Chromeceptin decreases the Phosphorylation levels of protein kinase B (AKT, Ser463) and rapamycin (mTOR, Ser 2481 and Ser 2448) in TS cells[1]. Chromeceptin represses the phosphorylation at ser371 in mTOR effectors ribosomal protein S6 kinase (p70S6K)[1].

[References]

[1]. Seol HS, et al. Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Sci Rep. 2020 Dec 8;10(1):21412.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆F₃N₃O

[ Molecular Weight ]:
359.34500

[ Exact Mass ]:
359.12500

[ PSA ]:
62.28000

[ LogP ]:
4.68988

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2.

Chem. Biol. 13 , 241-249, (2006)

Insulin-like growth factor 2 (IGF2) is a potent mitogen whose deregulation plays a role in developing liver, breast, and prostate cancers. Here, we take a small-molecule approach to investigate molecu...

Identification of bioactive molecules by adipogenesis profiling of organic compounds.

J. Biol. Chem. 278 , 7320-7324, (2003)

An important step in the postgenomic drug discovery is the construction of high quality chemical libraries that generate bioactive molecules at high rates. Here we report a cell-based approach to comp...