Chromeceptin
Modify Date: 2024-01-16 19:18:54
Chromeceptin structure
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Common Name | Chromeceptin | ||
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| CAS Number | 331859-86-0 | Molecular Weight | 359.34500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H16F3N3O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of ChromeceptinChromeceptin is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the Phosphorylation levels of AKT and mTOR[1]. |
| Name | Chromeceptin |
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| Synonym | More Synonyms |
| Description | Chromeceptin is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the Phosphorylation levels of AKT and mTOR[1]. |
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| Related Catalog | |
| In Vitro | Chromeceptin (94G6) (5 µM) inhibits IGF2 expression in Hep3B-derived TS cells in a time-dependent manner[1]. Chromeceptin decreases the Phosphorylation levels of protein kinase B (AKT, Ser463) and rapamycin (mTOR, Ser 2481 and Ser 2448) in TS cells[1]. Chromeceptin represses the phosphorylation at ser371 in mTOR effectors ribosomal protein S6 kinase (p70S6K)[1]. |
| References |
| Molecular Formula | C19H16F3N3O |
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| Molecular Weight | 359.34500 |
| Exact Mass | 359.12500 |
| PSA | 62.28000 |
| LogP | 4.68988 |
| Storage condition | 20°C |
| RIDADR | NONH for all modes of transport |
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| Precursor 3 | |
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| DownStream 0 | |
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Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2.
Chem. Biol. 13 , 241-249, (2006) Insulin-like growth factor 2 (IGF2) is a potent mitogen whose deregulation plays a role in developing liver, breast, and prostate cancers. Here, we take a small-molecule approach to investigate molecu... |
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Identification of bioactive molecules by adipogenesis profiling of organic compounds.
J. Biol. Chem. 278 , 7320-7324, (2003) An important step in the postgenomic drug discovery is the construction of high quality chemical libraries that generate bioactive molecules at high rates. Here we report a cell-based approach to comp... |
| 2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene 94G6 |
| 2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile |