3-(Trifluoromethyl)benzaldehyde

Names

[ CAS No. ]:
454-89-7

[ Name ]:
3-(Trifluoromethyl)benzaldehyde

[Synonym ]:
m-(Trifluoromethyl)benzaldehyde
α,α,α-Trifluoro-m-tolualdehyde
3-TRIFLUORMETHYLBENZALDEHYDE
3-(Trifluoromethyl)benzaldehyde
3-TRIFLUOROMETHYLBENZYLDEHYDE
m-Trifuoromethylbenzaldehyde
3-(trifluoromethyl)-benzaldehyde
3-trifluoromethylbenzaldehye
3-trifluromethyl-benzaldehyde
MFCD00003373
MTF-BAD
VHR CXFFF
EINECS 207-228-1
A,A,A-TRIFLUORO-M-TOLUALDEHYDE
A,A,A-TRIFLUORO-3-TOLUALDEHYDE
Benzaldehyde, 3-(trifluoromethyl)-
m-trifluorotolualdehyde
3-(trifluoromethyl)-benzaldehyd
M-TRIFLUOROMETHYLBENZALDEHYDE

Biological Activity

[Description]:

3-(Trifluoromethyl)benzaldehyde is an active compound, and can be used for the synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones. 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones are potent antitumor agents[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Le Floch C, et al. Synthesis of 2,3-di- and 2,2,3-trisubstituted-3-methoxycarbonyl-γ-butyrolactones as potent antitumor agents. Eur J Med Chem. 2015 Jan 7;89:654-70.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
176.3±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₅F₃O

[ Molecular Weight ]:
174.120

[ Flash Point ]:
68.3±0.0 °C

[ Exact Mass ]:
174.029251

[ PSA ]:
17.07000

[ LogP ]:
2.47

[ Vapour Pressure ]:
1.1±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.476

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H400

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)

[ WGK Germany ]:
3

[ HS Code ]:
2913000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2913000090

[ Summary ]:
HS: 2913000090 halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912 Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:none Most favored nation tariff:5.5% General tariff:30.0%

Articles

Synthesis of fluorinated materials catalyzed by proline or antibody 38C2 in ionic liquid. Kitazume T, et al.

J. Fluor. Chem. 121(2) , 205-12, (2003)