Col 003

Names

[ Name ]:
Col 003

Biological Activity

[Description]:

Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

HSP47:1.8 μM (IC50)

[References]

[1]. Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₁NO₄

[ Molecular Weight ]:
257.24

Related Compounds

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