glycyl-prolyl-glutamic acid

Names

[ Name ]:
glycyl-prolyl-glutamic acid

[Synonym ]:
Gly-pro-glu
GPE Glycyl-prolyl-glutamic acid
Glycyl-prolyl-glutamic acid
L-Glutamic acid,N-(1-glycyl-L-prolyl)

Biological Activity

[Description]:

Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection [1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

IC50: 14.7 μM (glutamate binds to NMDA receptor)[1]

[In Vitro]

Gly-Pro-Glu (0-100 μM) potentiates the potassium evoked release of both acetylcholine and dopamine, increases K+ evoked acetylcholine release even at concentrations of 0.1 nM and significantly enhances evoked dopamine release[1]. Gly-Pro-Glu (1-1000 μM) shows an inhibition of L-[3H]glutamate binding with an IC50 value of 14.7 μM[1].

[In Vivo]

Gly-Pro-Glu (300 mg; i.p. once per day; on day 0, 6 and 12) shows an in vivo effect protecting the temporal cortical somatostatinergic system from Abeta insult.[2]. Animal Model: Ovariectomized rats with Abeta25-35 injection[2] Dosage: 300 mg Administration: Intraperitoneal injection; 300 mg per day; on day 0, 6 and 12 Result: Recovered Abeta25-35-induced the reduction of somatostatin (SRIF) content and SRIF receptor density, and reduced the inhibitory effect of SRIF on adenylyl cyclase activity.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₉N₃O₆

[ Molecular Weight ]:
301.29600

[ Exact Mass ]:
301.12700

[ PSA ]:
153.52000

[ Storage condition ]:
Store at 0°C

[ Water Solubility ]:
H2O: >5mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells.

Pharm. Biol. 53(4) , 540-7, (2015)

Glycosmis parva Craib (Rutaceae) is reported to have cytotoxic and anti-inflammatory activities by decreasing COX-2 expression.To investigate the effect of G. parva on human colorectal cancer cells ex...

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

Bioorg. Med. Chem. Lett. 15 , 2279-83, (2005)

A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolid...

Phospholipids trigger Cryptococcus neoformans capsular enlargement during interactions with amoebae and macrophages.

PLoS Pathog. 7 , e1002047, (2011)

A remarkable aspect of the interaction of Cryptococcus neoformans with mammalian hosts is a consistent increase in capsule volume. Given that many aspects of the interaction of C. neoformans with macr...