BPDBA

Names

[ Name ]:
BPDBA

[Synonym ]:
N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide

Biological Activity

[Description]:

BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC50s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vivo]

BPDBA 被预测具有良好的口服吸收和血脑屏障穿透性能[1]。

[References]

[1]. Kragholm B, et al. Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. Biochem Pharmacol. 2013 Aug 15;86(4):521-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₀Cl₂N₂O

[ Molecular Weight ]:
363.28

[ Storage condition ]:
-20°C

Related Compounds

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