UNII:T875VN0D6E

Names

[ CAS No. ]:
303-26-4

[ Name ]:
UNII:T875VN0D6E

[Synonym ]:
EINECS 206-137-4
N-(4-CHLOROBENZHYDRYL)-PIPERAZINE
Hydroxyzine Related Compound A
1-(α-Phenyl-4-chlorobenzyl)piperazine
Norchlorcyclizine
1-(4-Chlorobenzhydry)piperazine
1-((4-Chlorophenyl)(phenyl)methyl)piperazine
1-[(4-Chlorophenyl)(phenyl)methyl]piperazine
1-(4-Chlorobenzhydryl) piperazine
1-(4-Chloro-α-phenylbenzyl)piperazine
1-(p-chlorobenzhydryl)piperazine
N-[(4-chlorophenyl)phenylmethyl]piperazine
1-(4-Chlorodiphenylmethyl)piperazine
1-(4-chlorobenzhydryl)-piperazine
1-(4-chlorobenzhydryl)
Piperazine, 1- (p-chloro-α-phenylbenzyl)-
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-
N-[1-(4-chlorophenyl)-1-(phenyl)methyl]piperazine
MFCD00005965
Piperazine, 1-[α-(4-chlorophenyl)benzyl]-
UNII:T875VN0D6E
4-(4-Chlorobenzhydryl)piperazine
(RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
1-[(4-chlorophenyl)phenylmethyl]-piperazine

Biological Activity

[Description]:

1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

1-(4-氯苄基)哌嗪是美氯嗪和氯环嗪的无活性代谢物，在羟嗪和西替利嗪的商业制剂中也发现它是一种杂质。1-(4-氯苄基)哌嗪已被用于合成电压门控钠通道 1.7 (Nav1.7) 抑制剂、抗癌剂和抗组胺剂。

[References]

[1]. Gaertner, HJ, Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973)

[2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965)

[3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm . Biomed. Anal.14(8-10)1371-1375(1996)

[4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014)

[5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015)

[6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012)

[7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
409.1±0.0 °C at 760 mmHg

[ Melting Point ]:
65-70 °C(lit.)

[ Molecular Formula ]:
C₁₇H₁₉ClN₂

[ Molecular Weight ]:
286.80

[ Flash Point ]:
193.3±26.5 °C

[ Exact Mass ]:
286.123688

[ PSA ]:
15.27000

[ LogP ]:
3.44

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.592

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL1772000

CHEMICAL NAME :: Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-

CAS REGISTRY NUMBER :: 303-26-4

BEILSTEIN REFERENCE NO. :: 0243027

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H19-Cl-N2

MOLECULAR WEIGHT :: 286.83

WISWESSER LINE NOTATION :: T6M DNTJ DYR&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TL1772000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%