Ro 20-0657/000

Names

[ Name ]:
Ro 20-0657/000

[Synonym ]:
ro-20-0657/000
unii-7439xp501f

Biological Activity

[Description]:

Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Robert E. London, et al. Nuclear magnetic resonance study of interaction of ligands with Streptococcus faecium dihydrofolate reductase labeled with [.gamma.-13C]tryptophan. Biochemistry 1982, 21, 18, 4450-4458.

[2]. van 't Klooster GA, et al. Determination of trimethoprim and its oxidative metabolites in cell culture media and microsomal incubation mixtures by high-performance liquid chromatography. J Chromatogr. 1992 Sep 2;579(2):354-60.

[3]. Tadić Đ, et al. Simultaneous determination of multiclass antibiotics and their metabolites in four types of field-grown vegetables. Anal Bioanal Chem. 2019 Aug;411(20):5209-5222.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₈N₄O₄

[ Molecular Weight ]:
306.31700

[ Exact Mass ]:
306.13300

[ PSA ]:
127.20000

[ LogP ]:
0.60870

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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