5-(2-Amino-2-oxoethyl)uridine

Names

[ Name ]:
5-(2-Amino-2-oxoethyl)uridine

[Synonym ]:
5-Cbmu
5-Carbamoylmethyluridine
5-uridinacetamide
5-(2-amino-2-oxoethyl)uridine
2-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]acetamide

Biological Activity

[Description]:

5-(2-Amino-2-oxoethyl)uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₅N₃O₇

[ Molecular Weight ]:
301.25

[ Exact Mass ]:
301.09100

[ PSA ]:
169.12000

Related Compounds

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