2-(Trimethylsilyl)ethanol
Names
[ CAS No. ]:
2916-68-9
[ Name ]:
2-(Trimethylsilyl)ethanol
[Synonym ]:
2-Hydroxyethyltrimethylsilane
Silane, (2-hydroxyethyl)trimethyl-
(2-Hydroxyethyl)Trimethylsilane
2-Trimethylsilylethanol
2-(Trimethylsilyl)ethanal
2-(trimethylsilyl)ethan-1-ol
MFCD00002825
trimethsilylethanol
Ethanol, 2-(trimethylsilyl)-
trimethylsilyl ethanol
2-(Trimethylsilyl)ethanol
2-TMS-ethanol
Ethanol, 2- (trimethylsilyl)-
2-Trimethylsilanyl-ethanol
EINECS 220-844-5
Chemical & Physical Properties
[ Density]:
0.825
[ Boiling Point ]:
145.0±13.0 °C at 760 mmHg
[ Melting Point ]:
0ºC
[ Molecular Formula ]:
C5H14OSi
[ Molecular Weight ]:
118.250
[ Flash Point ]:
50.6±0.0 °C
[ Exact Mass ]:
118.081390
[ PSA ]:
20.23000
[ LogP ]:
1.36
[ Vapour Pressure ]:
2.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.406
[ Storage condition ]:
0-6°C
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KM5480000
- CHEMICAL NAME :
- Ethanol, 2-(trimethylsilyl)-
- CAS REGISTRY NUMBER :
- 2916-68-9
- BEILSTEIN REFERENCE NO. :
- 1732034
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C5-H14-O-Si
- MOLECULAR WEIGHT :
- 118.28
- WISWESSER LINE NOTATION :
- Q2-SI-1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1122 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933- Volume(issue)/page/year: 229,1011,1976
Safety Information
[ Symbol ]:
GHS02
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R10;R36/37/38
[ Safety Phrases ]:
S16-S37/39-S26
[ RIDADR ]:
UN 1987 3/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
KM5480000
[ Packaging Group ]:
III
[ Hazard Class ]:
3
[ HS Code ]:
29310095
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2931900090
[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%
Articles
J. Med. Chem. 28(9) , 1309-13, (1985)
Reversible inhibitors for acetylcholinesterase, AcChE, have been studied. Sterically similar alcohols with tetra-substituted uncharged beta groups, (CH3)3SiCH2CH2OH (I), (CH3)3CCH2CH2OH (IA), and CH3S...
Generation of aza-ortho-xylylenes via ring opening of 2-(2-acylaminophenyl)aziridines: application in the construction of the communesin ring system.Org. Lett. 8 , 3995, (2006)
A new protocol for generating aza-ortho-xylylenes via acid-catalyzed or fluoride-promoted ring opening of 2-(2-acylaminophenyl)aziridines is described. This methodology has been exploited in the rapid...
Silicon compounds as substrates and inhibitors of acetylcholinesterase.Biochim. Biophys. Acta 791(2) , 278-80, (1984)
Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) ...