<Suppliers Price>

acetophenazine

Names

[ CAS No. ]:
2751-68-0

[ Name ]:
acetophenazine

[Synonym ]:
1-(10-{3-[4-(2-hydroxy-ethyl)-piperazino]-propyl}-phenothiazin-2-yl)-ethanone
Acetophenazinum [INN-Latin]
1-(10-{3-[4-(2-Hydroxy-aethyl)-piperazino]-propyl}-phenothiazin-2-yl)-aethanon
10-<3-(1-(2-Hydroxy-aethyl)-piperazinyl-(4))-propyl>-2-acetyl-phenothiazin
2-acetyl-10-(-3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl)phenothiazine
Acetophenazinum
1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone
Acetophenazina [INN-Spanish]
ACETOPHENAZINE
Acephenazinum
Tindal
1-(10-{3-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-propyl}-10H-phenothiazin-2-yl)-ethanone
Acetophenazine [INN]

Biological Activity

[Description]:

Acetophenazine, a phenothiazine derivative, is an antipsychotic agent. Acetophenazine primarily blocks dopamine D2 receptors in the brain. Acetophenazine can be used for researching psychotic disorders such as schizophrenia and anxious depression[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[Target]

D2 Receptor


[In Vivo]

Acetophenazine (2.4 mg/kg; i.h.; single dosage) significantly prolongs the time lapse from the first fight to submission and the actual fighting time to submission in mice[3]. Animal Model: C57BL mice (10-12 weeks)[3] Dosage: 2.4 mg/kg Administration: i.h.; single dosage Result: Significantly prolonged the time lapse from the first fight to submission and the actual fighting time to submission.

[References]

[1]. Azam Bazrafshan, et al. Acetophenazine versus chlorpromazine for schizophrenia. Cochrane Database of Systematic Reviews. 2015, Issue 4.

[2]. Hollister LE, et al. Acetophenazine and diazepam in anxious depressions. Arch Gen Psychiatry. 1971 Mar;24(3):273-8.

[3]. KNIGHT WR, HOLTZ JR, SPROGIS GR. ACETOPHENAZINE AND FIGHTING BEHAVIOR IN MICE. Science. 1963 Aug 30;141(3583):830-1.

Chemical & Physical Properties

[ Density]:
1.203g/cm3

[ Boiling Point ]:
608.7ºC at 760mmHg

[ Molecular Formula ]:
C23H29N3O2S

[ Molecular Weight ]:
411.56000

[ Flash Point ]:
321.9ºC

[ Exact Mass ]:
411.19800

[ PSA ]:
72.32000

[ LogP ]:
3.43270

[ Vapour Pressure ]:
7.83E-16mmHg at 25°C

[ Index of Refraction ]:
1.615

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds