3-Chloro-L-alanine

Names

[ Name ]:
3-Chloro-L-alanine

[Synonym ]:
(2R)-2-amino-3-chloropropanoic acid
DL-Alanine, 3-chloro-
L-Alanine, 3-chloro-
(R)-2-Amino-3-chloropropanoic acid
3-Chloro-L-alanine
2-amino-3-chloropropanoic acid
Alanine,3-chloro
L-Alanine,3-chloro
β-Chloro-L-alanine

Biological Activity

[Description]:

β-Chloro-L-alanine is a bacteriostatic amino acid analog which inhibits a number of enzymes, including threonine deaminase and alanine racemase.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[Target]

Bacterial[1]

[In Vitro]

β-Chloro-L-alanine can inhibit threonine deaminase, the branched-chain amino acid transaminase (transaminase B), L-aspartate-pdecarboxylase, alanine racemase and probably O-acetylserine sulfhydrylase. β-Chloro-L-alanine reversibly inhibits the Escherichia coli K-12 alanine-valine transaminase, transaminase C. This inhibition, along with the inhibition of transaminase B, account for the isoleucine-plus-valine requirement of Escherichia coli in the presence of β-Chloro-L-alanine. Salmonella typhimurium LT2 will grow in the presence of BCA if isoleucine and valine are added to the medium and presume that the growth requirement is due to the inhibition of transaminase B[1].

[References]

[1]. β-Chloro-L-alanine can inhibits threonine deaminase, the branched-chain amino acid transaminase (transaminase B), L-aspartate-pdecarboxylase, alanine racemase and probably O-acetylserine sulfhydrylase. β-Chloro-L-alanine reversibly inhibits the Escherichia coli

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
243.6±30.0 °C at 760 mmHg

[ Melting Point ]:
156 °C

[ Molecular Formula ]:
C₃H₆ClNO₂

[ Molecular Weight ]:
123.538

[ Flash Point ]:
101.1±24.6 °C

[ Exact Mass ]:
123.008705

[ PSA ]:
63.32000

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.499

[ Storage condition ]:
Store at 0°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
C

[ Safety Phrases ]:
24/25

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%