alpha-Hederin
Names
[ CAS No. ]:
27013-91-8
[ Name ]:
alpha-Hederin
[Synonym ]:
α-Hederin
(3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxyolean-12-en-28-oic acid
Alpha-hederin
glycosidel-e1
Olean-12-en-28-oic acid, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β)-
UNII:4H15F0GLV2
sapindosidea
HELIXIN
nepalin2
dipsacobioside
Hederoside B
koronaroside A
hederosidec
akebosidestc
taurosidee
A-HEDERIN
SAPINDOSIDE A
HEDERIN
Hederin, α-
alpha-Hederin
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
849.6±65.0 °C at 760 mmHg
[ Melting Point ]:
215ºC (dec.)
[ Molecular Formula ]:
C41H66O12
[ Molecular Weight ]:
750.956
[ Flash Point ]:
250.7±27.8 °C
[ Exact Mass ]:
750.455444
[ PSA ]:
195.60000
[ LogP ]:
8.37
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.601
[ Storage condition ]:
2~8℃
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RK0177800
- CHEMICAL NAME :
- Olean-12-en-28-oic acid, 3-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arab inopyranosyl) oxy)-23-hydroxy-, (3-beta,4-alpha)-
- CAS REGISTRY NUMBER :
- 27013-91-8
- BEILSTEIN REFERENCE NO. :
- 0076156
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C41-H66-O12
- MOLECULAR WEIGHT :
- 751.07
- WISWESSER LINE NOTATION :
- L F6 E6 B666 CUTJ F1 J1Q J1 N1 O1 RVQ U1 U1 IO- BT6OTJ DQ EQ CO- BT6OTJ CQ DQ EQ F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,545,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,545,1980
Safety Information
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
22
[ Safety Phrases ]:
22-45-24/25
[ RIDADR ]:
UN 1544
[ RTECS ]:
RK0177800
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Biol. Chem. 288(20) , 14000-17, (2013)
The interactions of triterpenoid monodesmosidic saponins, α-hederin and δ-hederin, with lipid membranes are involved in their permeabilizing effect. Unfortunately, the interactions of these saponins w...
Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.Biochemistry 48(15) , 3477-82, (2009)
Hederacoside C, alpha-hederin, and hederagenin are saponins of dry extracts obtained from the leaves of ivy (Hedera helix L.). Internalization of beta(2)-adrenergic receptor-GFP fusion proteins after ...
Participation of cholinergic pathways in α-hederin-induced contraction of rat isolated stomach strips.Phytomedicine 19(7) , 591-5, (2012)
The dry extract of Hedra helix leaves and its main active compounds, predominantly α-hederin and hederacoside C, has been traditionally believed to act spasmolytic. However, it has been recently prove...