EGFR-IN-71

Names

[ CAS No. ]:
2676155-98-7

[ Name ]:
EGFR-IN-71

Biological Activity

[Description]:

EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC50 values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

IC50: 3.7 μM (EGFR)[1]


[In Vitro]

EGFR-IN-71 (compound 41) (0-100 μM; 72 h) has inhibitory activity against U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 chordoma cell lines[1]. Cell Viability Assay[1] Cell Line: U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 Concentration: 0-100 μM Incubation Time: 72 h Result: Exhibited inhibitory activity against U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 chordoma cell lines with IC50s of 9.1 μM, 16 μM, 0.48 μM, 25 μM, 0.96 μM and 8.0 μM, respectively.

[References]

[1]. Bieberich AA, et al. Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform. Sci Rep. 2022 Jul 27;12(1):12820.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H9ClIN3

[ Molecular Weight ]:
405.62

Related Compounds

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