B-Raf IN 5

Names

[ Name ]:
B-Raf IN 5

Biological Activity

[Description]:

B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> Raf

[References]

[1]. Schneider M, et al. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding. J Med Chem. 2022;65(2):1552-1566.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₈ClF₃N₆O₃S₂

[ Molecular Weight ]:
583.01

B-Raf IN 5

Names

Biological Activity

Chemical & Physical Properties

Related Compounds