ROCK-IN-9

Names

[ Name ]:
ROCK-IN-9

Biological Activity

[Description]:

ROCK-IN-9 (Compound T345) is a ROCK inhibitor. ROCK-IN-9 shows cytotoxicity in HepG2 cell, with an IC50 of 40.8 μM. ROCK-IN-9 has good pharmacokinetic properties in mice, and shows high in vivo exposure and oral bioavailability at lower doses[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK

Signaling Pathways >> Stem Cell/Wnt >> ROCK

Signaling Pathways >> TGF-beta/Smad >> ROCK

[References]

[1]. Li, Jinping, et al. Rock inhibitor, preparation method therefor and use thereof. WO2021093795.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₀FN₅O₂

[ Molecular Weight ]:
381.40

Related Compounds

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