M1/M2/M4 muscarinic agonist 3

Names

[ CAS No. ]:
2640109-28-8

[ Name ]:
M1/M2/M4 muscarinic agonist 3

Biological Activity

[Description]:

M1/M2/M4 muscarinic agonist 3 (compound 45) is a muscarinic mAChR M1/M2/M4 agonist with EC50s of 3.2 nM, 32 nM and 1.7 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> GPCR/G Protein >> mAChR
Research Areas >> Neurological Disease

[Target]

EC50: 3.2 nM (M1 muscarinic receptor), 32 nM (M2 muscarinic receptor), 1.7 nM (M4 muscarinic receptor)[1]


[References]

[1]. Thomson C G et al. Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists[J]. ACS Medicinal Chemistry Letters, 2023.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H31FN2O3

[ Molecular Weight ]:
402.50

Related Compounds

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