Menthyl acetate

Names

[ Name ]:
Menthyl acetate

[Synonym ]:
(-)-Menthyl Acetate
(-)-Menthol acetate
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl acetate
(2S,1R,5R)-2-isopropyl-5-methylcyclohex-1-yl acetate
l-(-)-Menthyl acetate
(-)-Acetoxy-p-menthane
Acetic acid,L
EINECS 220-076-0
(1R)-(−)-Menthyl acetate
MENTHYL ACETATE, (-)-
l-Menthol acetate
Menthol, acetate, (1R,3R,4S)-(-)-
(1R)-(-)-Menthyl acetate
(1R,2S,5R)-rel-2-Isopropyl-5-methylcyclohexyl acetate
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate, (1R,2S,5R)-
L-Menthyl acetate
MFCD00001482
L-p-Menth-3-yl acetate
Cyclohexan-1-ol,acetate,L
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexylacetat
(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl acetate
menthyl (1R,2S,5R)-(-)-acetate
Menthyl acetate
L-(-)-2-isopropyl-5-methylcyclohexanol

Biological Activity

[Description]:

Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Tokuoka Y, et al. Enhancement in skin permeation of 5-aminolevulinic acid using l-menthol and its derivatives.Drug Dev Ind Pharm. 2008 Jun;34(6):595-601.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
229.1±8.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₂₂O₂

[ Molecular Weight ]:
198.302

[ Flash Point ]:
92.2±0.0 °C

[ Exact Mass ]:
198.161987

[ PSA ]:
26.30000

[ LogP ]:
4.10

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.448

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AI5900000

CHEMICAL NAME :: Acetic acid, p-menth-3-yl ester, l-

CAS REGISTRY NUMBER :: 2623-23-6

BEILSTEIN REFERENCE NO. :: 2208505

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H22-O2

MOLECULAR WEIGHT :: 198.34

WISWESSER LINE NOTATION :: L6TJ AY1&1 BOV1 D1 -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,477,1976 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,477,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,477,1976

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NA 1993 / PGIII

[ WGK Germany ]:
3

[ RTECS ]:
AI5900000

Precursor & DownStream

Precursor

DownStream

Articles

Organoleptic Characteristics of Flavor Materials Mosciano, G.

Perfum. Flavor. 6th ed., 28 , 77, (2003)

Mosciano, G.

Perfum. Flavor. 4th ed., 30 , 55, (2005)

Related Compounds

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​Menthyl acetate