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phyllomedusin

Names

[ CAS No. ]:
26145-48-2

[ Name ]:
phyllomedusin

Biological Activity

[Description]:

Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus[1][2][3].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

NK1


[In Vitro]

Phyllomedusin increases neuronal excitation with psychoactive and behavioral responses[4]. Phyllomedusin can cause smooth muscle contraction and vasodilatation[4].

[In Vivo]

Phyllomedusin (30-300 μg/kg, i.p.) delays gastric emptying in conscious rats[2]. Phyllomedusin (0.1 and 5 μg/kg, i.v.) has stimulant activity on the stomach of the anaesthetized rat[3]. Animal Model: Conscious rats[2]. Dosage: 30, 100, 300 μg/kg Administration: Intraperitoneal injection (i.p.) Result: Caused 75% delay in gastric emptying in conscious rats.

[References]

[1]. Ganjiwale AD, et al. Three-dimensional structure of Phyllomedusin, a NK1 receptor agonist bound to dodecylphosphocholine micelles. J Struct Biol. 2009 Aug;167(2):176-84.  

[2]. Bertaccini G, et al. Effect of substance P and its natural analogues on gastric emptying of the conscious rat. Br J Pharmacol. 1981 Feb;72(2):221-3.  

[3]. Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6.  

[4]. Sacco MA, et al. Kambo: Natural drug or potential toxic agent? A literature review of acute poisoning cases. Toxicol Rep. 2022 Apr 15;9:905-913.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C52H82N16O13S

[ Molecular Weight ]:
1171.372

[ Exact Mass ]:
1170.596802

[ LogP ]:
-1.52

[ Index of Refraction ]:
1.668

Related Compounds

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