N,2-Dimethylalanine

Names

[ Name ]:
N,2-Dimethylalanine

[Synonym ]:
N-Methyl-a-aminoisobutyric acid
2,N-Dimethylalanine (2-(Methylamino)-2-methylpropionic acid
N,2-Dimethylalanine
2 methylaminoisobutyrate
MFCD00004191
2,N-Dimethylalanine
N,2-Dimethylalanine Hydrate
2-(MethylaMino)isobutyric Acid Hydrate
Alanine, N,2-dimethyl-
2-(Methylamino)-2-methylpropionic acid
2-Methylaminoisobutyric acid
EINECS 219-898-2
2-(Methylamino)isobutyric acid
N-Methyl-α-aminoisobutyric acid

Biological Activity

[Description]:

α-(Methylamino)isobutyric acid is a specific substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

ATA3 is a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. ATA1 (also known as GlnT) and ATA2 (also known as SAT2), have been cloned from rat and human tissues. These transporters mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner[1].

[References]

[1]. M Sugawara, et al. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta. 2000 Dec 20;1509(1-2):7-13.

[2]. Y Kudo, et al. Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. Placenta. 2002 Aug;23(7):536-41.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
192.5±23.0 °C at 760 mmHg

[ Melting Point ]:
> 300ºC

[ Molecular Formula ]:
C₅H₁₁NO₂

[ Molecular Weight ]:
117.146

[ Flash Point ]:
70.2±22.6 °C

[ Exact Mass ]:
117.078979

[ PSA ]:
49.33000

[ LogP ]:
-0.10

[ Vapour Pressure ]:
0.2±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.442

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

Bioorg. Med. Chem. 19 , 6409-18, (2011)

The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...

Unique antitumour effects of L-2,4 diaminobutyric acid on cultured hepatoma cells.

Anticancer Res. 23 , 1245-1248, (2003)

A single hepatoma cell line was grown in vitro and incubated with L-2,4 diaminobutyric acid (DAB), a non-metabolizable amino acid, under various conditions. The tumour cells were irreversibly damaged ...

Integrin participates in the effect of thyroxine on plasma membrane in immature rat testis.

Biochim. Biophys. Acta 1830(3) , 2629-37, (2013)

The secretory activity of Sertoli cells (SC) is dependent on ion channel functions and protein synthesis and is critical to ongoing spermatogenesis. The aim of this study was to investigate the mechan...

Related Compounds

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