mGAT-IN-1

Names

[ Name ]:
mGAT-IN-1

Biological Activity

[Description]:

mGAT-IN-1 (compound 28) is a potent and non-selective GAT inhibitor. mGAT-IN-1 has a high inhibitory potency toward mGAT3, with an IC50 of 2.5 μM and pIC50 of 5.61[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

IC50: 2.5 μM (mGAT3); pIC50: 5.06 ± 0.02 (mGAT1), 5.35 ± 0.08 (mGAT2), 5.61 ± 0.07 (mGAT3), 5.21 ± 0.05 (mGAT4)[1]

[References]

[1]. Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₄ClN₃O₂S₂

[ Molecular Weight ]:
544.17

Related Compounds

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