N,N-Dimethylglycine hydrochloride

Names

[ Name ]:
N,N-Dimethylglycine hydrochloride

[Synonym ]:
Glycine, N,N-dimethyl-, hydrochloride (1:1)
N,N-Dimethyl glycine hydrochloride
Me2NCH2CO2H hydrochloride
glycine-N',N'-dimethylamide hydrochloride
n,n-dimethylglycine hydrochloride(1:1)
Glycine,N,N-dimethyl-,hydrochloride
Me2NCH2CO2H*HCl
MFCD00012610
N,N-Dimethylglycine hydrochloride
N,N-Dimethylglycine hydrochloride (1:1)
N-Methylsarcosine hydrochloride
N,N-Dimethylglycine Hcl
(Dimethylamino)acetic acid hydrochloride
N,N-dimethylglycine*HCl
N,N-dimethyl-glycine hydrochloride
N,N-Dimethylaminoacetic acid hydrochloride
N,N-Dimethylglycinium chloride
EINECS 219-648-2
Dimethylglycine hydrochloride

Biological Activity

[Description]:

N,N-Dimethylglycine hydrochloride is a Glycine (HY-Y0966) derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.069g/cm3

[ Boiling Point ]:
175.2ºC at 760 mmHg

[ Melting Point ]:
189-194 °C(lit.)

[ Molecular Formula ]:
C₄H₁₀ClNO₂

[ Molecular Weight ]:
139.581

[ Flash Point ]:
59.8ºC

[ Exact Mass ]:
139.040009

[ PSA ]:
40.54000

[ LogP ]:
0.43460

[ Vapour Pressure ]:
0.556mmHg at 25°C

[ Water Solubility ]:
100 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB9995000

CHEMICAL NAME :: Glycine, N,N-dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 2491-06-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H9-N-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,198,1992

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
MB9995000

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Exposure to the proton scavenger glycine under alkaline conditions induces Escherichia coli viability loss.

PLoS ONE 8(3) , e60328, (2013)

Our previous work described a clear loss of Escherichia coli (E. coli) membrane integrity after incubation with glycine or its N-methylated derivatives N-methylglycine (sarcosine) and N,N-dimethylglyc...

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.

Am. J. Clin. Nutr. 97(6) , 1217-27, (2013)

Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In hum...

Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine.

Am. J. Clin. Nutr. 97(6) , 1252-9, (2013)

Folate, choline, and betaine participate in homocysteine metabolism. It is not known whether they interact during pregnancy.The objective was to investigate how folate status affects choline, betaine,...