LDHA/PDKs-IN-2

Names

[ CAS No. ]:
2490699-44-8

[ Name ]:
LDHA/PDKs-IN-2

Biological Activity

[Description]:

LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC50 of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> PDK-1
Research Areas >> Cancer

[References]

[1]. Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H20N2O5

[ Molecular Weight ]:
332.35

Related Compounds

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