2490699-44-8

2490699-44-8 structure

Name: LDHA/PDKs-IN-2
Chemical Name: LDHA/PDKs-IN-2
CAS Number: 2490699-44-8
Molecular Formula: C₁₇H₂₀N₂O₅
Molecular Weight: 332.35
Catalog: Signaling Pathways PI3K/Akt/mTOR PDK-1
Create Date: 2022-06-04 11:25:30
Modify Date: 2024-01-06 19:12:31
LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC50 of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases[1].

Name	LDHA/PDKs-IN-2

Description	LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC50 of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> PDK-1 Research Areas >> Cancer
References	[1]. Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579.

Molecular Formula	C₁₇H₂₀N₂O₅
Molecular Weight	332.35