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LDHA-IN-4

Names

[ CAS No. ]:
1370290-34-8

[ Name ]:
LDHA-IN-4

[Synonym ]:
Propanedioic acid, 2-[[4-[4-[[3-[(2-methyl-6-benzothiazolyl)amino]-3-oxopropyl]amino]-4-oxobutyl]phenyl]methyl]-
{4-[4-({3-[(2-Methyl-1,3-benzothiazol-6-yl)amino]-3-oxopropyl}amino)-4-oxobutyl]benzyl}malonic acid
AZ-33

Biological Activity

[Description]:

AZ-33 is a selective lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 0.5 μM and a Kd of 0.093 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

[References]

[1]. Ward RA,et al. Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. J Med Chem. 2012 Apr 12;55(7):3285-306.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
843.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H27N3O6S

[ Molecular Weight ]:
497.563

[ Flash Point ]:
464.2±34.3 °C

[ Exact Mass ]:
497.162048

[ LogP ]:
2.30

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.659

Related Compounds