Ro 64-5229

Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1[1].

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

mGlu2[1].

RO 64-5229 (50 µM) 降低神经连接蛋白 1 的突触前抑制作用[1]。 RO 64-5229 (0.1, 0.3, 1 µM; 20 min) 在 HEK-mGluR2 细胞中抑制 neuroligin 1 ectodomain (Ecto-NL1; mGluR2 激活剂) 对 Forskolin 的抑制活性 (Ecto-NL1 降低了 Forskolin 诱导的 cAMP 形成)[1]。 Immunofluorescence[1] Cell Line: HEK-mGluR2 cells Concentration: 0.1, 0.3, 1 µM Incubation Time: 20 min Result: Inhibited activity of Ecto-NL1( mGluR2 activator).

[1]. Gjørlund MD, et al. Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2. Front Mol Neurosci. 2017 May 3;10:116.