Oseltamivir phosphate
Names
[ CAS No. ]:
204255-11-8
[ Name ]:
Oseltamivir phosphate
[Synonym ]:
Ro-64-0796/002
Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(3-pentanyloxy)-1-cyclohexene-1-carboxylate phosphate (1:1)
Oseltamivir phosphate
Tamiflu
Oselt
MFCD08059548
Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate phosphate (1:1)
GS-4104/002
Osteltamivir phosphate
ethyl (3R,4R,5S)-4-(acetylamino)-5-amino-3-(1-ethylpropoxy)cyclohex-1-ene-1-carboxylate phosphate
ethyl (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate phosphate (1:1)
Phosphorosäure-ethyl-(3R,4R,5S)-4-(acetylamino)-5-amino-3-(1-ethylpropoxy)cyclohex-1-en-1-carboxylat(1:1)
Ro 64-0796/002
NTERMEDIATES OF OSELTAMIVIR
1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R,4R,5S)-, phosphate (1:1)
acide phosphorique - (3R,4R,5S)-4-(acétylamino)-5-amino-3-(1-éthylpropoxy)cyclohex-1-ène-1-carboxylate d'éthyle (1:1)
OseltaMivir Acid-D3 Phosphate
Oseltamivir phosphat
Oseltamir phosphate
Oseltamivir (phosphate)
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Influenza A and B[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.08g/cm3
[ Boiling Point ]:
473.3ºC at 760 mmHg
[ Melting Point ]:
196-198°C
[ Molecular Formula ]:
C16H31N2O8P
[ Molecular Weight ]:
410.400
[ Flash Point ]:
240ºC
[ Exact Mass ]:
410.181793
[ PSA ]:
178.22000
[ LogP ]:
1.44800
[ Storage condition ]:
-20°C Freezer
MSDS
Safety Information
[ Hazard Codes ]:
Xn
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
PLoS ONE 10(3) , e0118780, (2015)
Ferrets are the preferred animal model to assess influenza virus infection, virulence and transmission as they display similar clinical symptoms and pathogenesis to those of humans. Measures of diseas...
Simvastatin modulates cellular components in influenza A virus-infected cells.Int. J. Mol. Med. 34(1) , 61-73, (2014)
Influenza A virus is one of the most important health risks that lead to significant respiratory infections. Continuous antigenic changes and lack of promising vaccines are the reasons for the unsucce...
Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.Drug Metab. Dispos. 42(9) , 1522-31, (2014)
Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 pr...