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RO-5353

Names

[ CAS No. ]:
1360821-61-9

[ Name ]:
RO-5353

[Synonym ]:
Spiro[pyrrolidine-3,6'-[6H]thieno[3,2-b]pyrrole]-5-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-4',5'-dihydro-5'-oxo-, (2S,3R,4R,5R)-
(2S,3R,4R,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

Biological Activity

[Description]:

A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg.

[References]

References 1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
759.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H29Cl2FN4O4S

[ Molecular Weight ]:
619.534

[ Flash Point ]:
412.9±32.9 °C

[ Exact Mass ]:
618.127075

[ LogP ]:
6.32

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.663

Related Compounds