A2A/A1 AR antagonist-1

Names

[ Name ]:
A2A/A1 AR antagonist-1

Biological Activity

[Description]:

A2A/A1 AR antagonist-1 (compound 1a) is dual potent A2A/A1 AR antagonist with Kis of 5.58 and 24.2 nM, respectively. A2A/A1 AR antagonist-1 has the potential for the research of ischemic stroke[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[References]

[1]. Tang ML, et al. Discovery of Pyridone-Substituted Triazolopyrimidine Dual A2A/A1 AR Antagonists for the Treatment of Ischemic Stroke. ACS Med Chem Lett. 2022;13(3):436-442. Published 2022 Feb 21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₂N₆O₂

[ Molecular Weight ]:
308.29

Related Compounds

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