A2A receptor antagonist 1

Names

[ CAS No. ]:
443103-97-7

[ Name ]:
A2A receptor antagonist 1

Biological Activity

[Description]:

A2A receptor antagonist 1 is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Research Areas >> Cancer
Research Areas >> Neurological Disease

[Target]

Ki: 4 nM (adenosine A2A receptor), 264 nM (A1 receptor)[1]


[References]

[1]. Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9.


[Related Small Molecules]

CGS 21680 hydrochloride | Preladenant | ZM 241385 | CPI-444 | SCH 58261 | Vipadenant | Istradefylline | Tozadenant | AZD-4635 | Capadenoson | 2-CL-IB-MECA | PSB-12379 | CD73-IN-1 | IB-MECA | Diprophylline

Chemical & Physical Properties

[ Molecular Formula ]:
C16H12FN5O

[ Molecular Weight ]:
309.3

[ Storage condition ]:
-20℃

Related Compounds