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AZD-4635

Names

[ CAS No. ]:
1321514-06-0

[ Name ]:
AZD-4635

[Synonym ]:
AZD-4635
AZD4635
6-(2-Chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine

Biological Activity

[Description]:

AZD4635 is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Research Areas >> Cancer

[Target]

Ki: 1.7 nM (A2AR)


[References]

[1]. Alexandra Borodovsky, et al. Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580.


[Related Small Molecules]

CGS 21680 hydrochloride | Preladenant | ZM 241385 | CPI-444 | SCH 58261 | Vipadenant | Istradefylline | Tozadenant | Capadenoson | 2-CL-IB-MECA | PSB-12379 | CD73-IN-1 | IB-MECA | Diprophylline | Doxofylline

Chemical & Physical Properties

[ Molecular Formula ]:
C15H11ClFN5

[ Molecular Weight ]:
315.73300

[ Exact Mass ]:
315.06900

[ PSA ]:
77.58000

[ LogP ]:
3.86490

[ Storage condition ]:
-20℃

Related Compounds